Characterization of specific receptors for atrial natriuretic factor in bovine adrenal zona glomerulosa.

@article{Lan1984CharacterizationOS,
  title={Characterization of specific receptors for atrial natriuretic factor in bovine adrenal zona glomerulosa.},
  author={Andr{\'e} De L{\'e}an and Jolanta Gutkowska and Normand McNicoll and Peter W. Schiller and Marc Cantin and Jacques J Genest},
  journal={Life sciences},
  year={1984},
  volume={35 23},
  pages={
          2311-8
        }
}
We have recently shown that synthetic rat atrial natriuretic factor (ANF) directly inhibits mineralocorticoid and glucocorticoid secretion in cultured bovine adrenal cells with a potency of 100 pM. [125I]iodo-ANF was used in the present study to characterize potential receptor sites in bovine zona glomerulosa membranes. ANF binds to a class of high affinity binding sites with a pK of 10.2 and a density of 1.3 pmol/mg protein. Detailed competition curves with ANF document a class of high… CONTINUE READING
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