Characterization of specific nucleosomal states by use of selective substitution reagents in model octamer and tetramer structures.

Abstract

Packaging of the DNA in nucleosomes restricts its access to regulatory factors and enzymatic complexes, making a local remodeling of the nucleosome structure a prerequisite to the establishment of protein-DNA interactions. The use of an experimental system in which one nucleosome is reconstituted on a topologically constrained DNA minicircle allows the… (More)

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