Characterization of spatial and temporal expression pattern of Col15a1b during zebrafish development.

Abstract

In mammals, collagen XV is primarily expressed in skeletal and cardiac muscles, and loss of its expression in mice results in a mild skeletal myopathy. We recently identified Col15a1a, a zebrafish ortholog of the human collagen XV gene which expression was restricted to notochord in embryos. Col15a1a knockdown led to defects in muscle maintenance via Shh… (More)
DOI: 10.1016/j.gep.2010.10.004

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