Characterization of soluble forms of nonchimeric type V adenylyl cyclases.

@article{Scholich1997CharacterizationOS,
  title={Characterization of soluble forms of nonchimeric type V adenylyl cyclases.},
  author={Klaus Scholich and Ann J Barbier and J B Mullenix and Tarun B. Patel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 7},
  pages={2915-20}
}
Type V adenylyl cyclase (ACV) belongs to the family of Ca2+-inhibited cyclases. We have generated two soluble forms of the enzyme containing the C1 or C1a region (which lacks the C-terminal 112 amino acids) linked to the C2 domain and compared their regulation with the full-length ACV. All three forms of ACV were stimulated by the alpha subunit of the stimulatory G protein Gs (G(s alpha)) and forskolin. However, the synergistic stimulation by both these activators was markedly enhanced in the… CONTINUE READING

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