Characterization of soluble forms of nonchimeric type V adenylyl cyclases.

  title={Characterization of soluble forms of nonchimeric type V adenylyl cyclases.},
  author={Klaus Scholich and Ann J Barbier and J B Mullenix and Tarun B. Patel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 7},
Type V adenylyl cyclase (ACV) belongs to the family of Ca2+-inhibited cyclases. We have generated two soluble forms of the enzyme containing the C1 or C1a region (which lacks the C-terminal 112 amino acids) linked to the C2 domain and compared their regulation with the full-length ACV. All three forms of ACV were stimulated by the alpha subunit of the stimulatory G protein Gs (G(s alpha)) and forskolin. However, the synergistic stimulation by both these activators was markedly enhanced in the… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 22 extracted citations

Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase.

American journal of physiology. Renal physiology • 2000
View 16 Excerpts
Highly Influenced

Catalytic mechanism and regulation of mammalian adenylyl cyclases.

Molecular pharmacology • 1998
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…