Characterization of single potassium channels in mouse pancreatic acinar cells.

@article{Schmid1995CharacterizationOS,
  title={Characterization of single potassium channels in mouse pancreatic acinar cells.},
  author={Andreas Schmid and Irene Schulz},
  journal={The Journal of physiology},
  year={1995},
  volume={484 ( Pt 3)},
  pages={661-76}
}
1. Single K(+)-selective channels with a conductance of about 48 pS (pipette, 145 mM KCl; bath, 140 mM NaCl + 4.7 mM KCl) were recorded in the patch-clamp whole-cell configuration in isolated mouse pancreatic acinar cells. 2. Neither application of the secretagogues acetylcholine (second messenger, inositol 1,4,5-trisphosphate) or secretin (second messenger, cAMP), nor addition of the catalytic subunit of protein kinase A to the pipette solution changed the activity of the 48 pS K+ channel. 3… CONTINUE READING