Characterization of silodosin and naftopidil in the treatment of bladder dysfunction in the spontaneously hypertensive rat.

@article{Saito2013CharacterizationOS,
  title={Characterization of silodosin and naftopidil in the treatment of bladder dysfunction in the spontaneously hypertensive rat.},
  author={Motoaki Saito and Shogo Shimizu and Fumiya Ohmasa and Ryo Oikawa and Panagiota Tsounapi and Fotios Dimitriadis and Yukako Kinoshita and Keisuke Satoh},
  journal={Neurourology and urodynamics},
  year={2013},
  volume={32 4},
  pages={393-8}
}
PURPOSE As increasing evidence suggest that α(1)-blockers prevent benign prostatic hyperplasia related overactive bladder and nocturia in the human, we investigated the effects of silodosin and naftopidil on hypertension-related bladder dysfunction in the spontaneously hypertensive rat (SHR) model. MATERIALS AND METHODS Twelve-week-old male SHRs received no treatment or treatment with silodosin (100 µg/kg, p.o.) or naftopidil (10 or 30 mg/kg, p.o.) once daily for 6 weeks. Wistar rats were… CONTINUE READING
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