Characterization of sil in invasive group A and G streptococci: antibodies against bacterial pheromone peptide SilCR result in severe infection.

@article{MichaelGayego2013CharacterizationOS,
  title={Characterization of sil in invasive group A and G streptococci: antibodies against bacterial pheromone peptide SilCR result in severe infection.},
  author={Ayelet Michael-Gayego and Mary Dan-Goor and Joseph Jaffe and Carlos Hidalgo-Grass and Allon E. Moses},
  journal={Infection and immunity},
  year={2013},
  volume={81 11},
  pages={4121-7}
}
Group G beta-hemolytic streptococcus (GGS) strains cause severe invasive infections, mostly in patients with comorbidities. GGS is known to possess virulence factors similar to those of its more virulent counterpart group A streptococcus (GAS). A streptococcal invasion locus, sil, was identified in GAS. sil encodes a competence-stimulating peptide named SilCR that activates bacterial quorum sensing and has the ability to attenuate virulence in GAS infections. We found that sil is present in… CONTINUE READING

Similar Papers

Loading similar papers…