Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33.

  title={Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33.},
  author={Ann L. Cornish and Sylvie Freeman and GeoffreyM. Forbes and Jian Ni and Mei Zhang and M. F. J. Cepeda and Reiner Gentz and Meena Augustus and Kenneth C. Carter and Paul R. Crocker},
  volume={92 6},
We describe the characterization of siglec-5 (sialic acid-binding Ig-like lectin-5), a novel transmembrane member of the immunoglobulin superfamily, highly related to the myeloid antigen, CD33. A full-length cDNA encoding siglec-5 was isolated from a human activated monocyte cDNA library. Sequencing predicted that siglec-5 contains four extracellular immunoglobulin-like domains, the N-terminal two of which are 57% identical to the corresponding region of CD33. The cytoplasmic tail is also… CONTINUE READING
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