Characterization of sheep seminal vesicle cells-a new tool for studying genotoxic effects in vitro.

@article{Foth1992CharacterizationOS,
  title={Characterization of sheep seminal vesicle cells-a new tool for studying genotoxic effects in vitro.},
  author={J. Foth and Rainer Schnitzler and Martine J Jager and Manfred Koob and Manfred Metzler and Gisela H. Degen},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={1992},
  volume={6 3},
  pages={219-25}
}
Recently, primary cultures consisting mostly of fibroblasts and up to 8% epithelial cells have been derived from ram seminal vesicles (SEMV), which contain high levels of prostaglandin H synthase (PHS). PHS-peroxidase can catalyse the metabolic activation of several xenobiotics, for example diethylstilboestrol (DES). Thus SEMV cells can be a useful tool for investigating whether PHS has a role in mediating the adverse genotoxic effects of such substances, provided that a suitable endpoint for… CONTINUE READING