Characterization of sexual dimorphism in the human corpus callosum

@article{Dubb2003CharacterizationOS,
  title={Characterization of sexual dimorphism in the human corpus callosum},
  author={Abraham Dubb and Ruben C. Gur and Brian B. Avants and James C. Gee},
  journal={NeuroImage},
  year={2003},
  volume={20},
  pages={512-519}
}
  • A. Dubb, R. Gur, +1 author J. Gee
  • Published 1 September 2003
  • Computer Science, Medicine, Psychology
  • NeuroImage
Despite decades of research, there is still no agreement over the presence of gender-based morphologic differences in the human corpus callosum. We approached the problem using a highly precise computational technique for shape comparison. Starting with a prospectively acquired sample of cranial MRIs of healthy volunteers (age ranges 18-84), the variations of individual callosa are quantified with respect to a reference callosum shape in the form of Jacobian determinant maps derived from the… 
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The results suggest that the shape of the corpus callosum is characterized by low levels of morphological integration, which explains the large variability.
[Sexual dimorphism of the human corpus callosum--digital morphometric study].
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The results suggest that the problem of sexual dimorphism of the corpus callosum is very complex, because the identical variables do not exhibit the same behavior in males and in females, implicating that these variables even cannot be simply compared between the sexes.
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These findings implicate sex differences in CC morphology across the lifespan that are localized to the genu, which appear to mediate neuropsychological functions.
Sex differences of human corpus callosum revealed by polar coordinate system: magnetic resonance imaging study.
BACKGROUND Evaluation of morphological and size changes related to various pathological conditions of the corpus callosum (CC) requires the data about sex dimorphism of the CC. The purpose of our
Gender differences in the rat corpus callosum: An ultrastructure study
TLDR
The findings of the present study indicated region‐specific differences in the myelinated, unmyelinated or the ratio of myelination/total axons in the CC between male and female rats.
Sexual dimorphism and handedness in the human corpus callosum based on magnetic resonance imaging
TLDR
Mid-sagittal magnetic resonance images of 80 normal individuals were analyzed to assess whether or not the morphology of the corpus callosum and its parts are related to sex and handedness, which increased significantly with sex in males and no age-related changes were found.
Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome
TLDR
Novel methods were used to map the corpus callosum morphology of children with chromosome 22q11.2 deletion syndrome to reveal intricate relationships between genetic and disease-specific factors in the callosal anatomy and the potential impact of those changes on cognitive functions.
Sexual dimorphism revealed in the structure of the mouse brain using three-dimensional magnetic resonance imaging
TLDR
Using high-definition 3D MRI on a normal inbred mouse strain, many sex-associated statistically significant differences in brain structures are mapped in detail, finding males were larger in the thalamus, primary motor cortex and posterior hippocampus, while females were smaller in posterior hypothalamic area, entorhinal cortex and anterior hippocampus.
Effects of age and gender on spatial orientation of human corpus callosum in healthy Koreans
TLDR
M measuring some variables reflecting the spatial orientation of CC on magnetic resonance imaging in Koreans confirmed that the spatial Orientation of CC is influenced by age and gender.
Morphometric MRI evaluation of corpus callosum and ventricles in normal adults
TLDR
Findings show that there are differences between the averages of some indices of corpus callosum of the population and the other populations.
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TLDR
While there was no conclusive evidence of sexual dimorphism in the area of the corpus callosum or its subdivisions, there was significant sex differences in shape, which could, in part, underlie gender-related differences in behavior and neuropsychological function.
Sexual Dimorphism in the Corpus Callosum: Methodological Considerations in MRI Morphometry
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Three strategies intended to normalize for average differences in brain size between the sexes, as well as five different normalization variables, were contrasted and evaluated and suggest that different approaches to normalization and analysis are not necessarily equivalent and interchangeable.
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The posterior part of the female corpus callosum was described to be larger and more bulbous than its male counterpart and the "rotatory diameter measurement" was performed and no differences between the sexes were seen either for the splenium corporis callosi or for the other parts of the corpus callosi.
Sexual Dimorphism in the Corpus Callosum: A Characterization of Local Size Variations and a Classification Driven Approach to Morphometry
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Preliminary observations suggest a sex difference in the shape and surface area of the human corpus callosum, and this finding could be related to possible gender differences in the degree of lateralization for visuospatial functions.
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Both GM and WM volumes correlated moderately with global, verbal, and spatial performance across groups, however, the regression of cognitive performance and WM volume was significantly steeper in women.
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