Characterization of semi-solid Self-Emulsifying Drug Delivery Systems (SEDDS) of atorvastatin calcium by Raman image spectroscopy and chemometrics.

A methodology based on Raman image spectroscopy and chemometrics for homogeneity evaluation of formulations containing atorvastatin calcium in Gelucire(®) 44/14 is presented. In the first part of the work, formulations with high amounts of Gelucire(®) 44/14 (80%) and solvents of different polarities (diethylene glycol monoethyl ether, propyleneglycol… (More)