Characterization of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis from eastern China.

@article{Sheng2008CharacterizationOR,
  title={Characterization of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis from eastern China.},
  author={J Sheng and Junming Li and G Sheng and Huiye Qiu and Han-ju Huang and H Cao and Yang Lu and Xin-xin Deng},
  journal={Journal of applied microbiology},
  year={2008},
  volume={105 3},
  pages={904-11}
}
AIMS The aim of this study was to investigate the features of rpoB gene mutations associated with Rifampin (RIF) resistance in Mycobacterium tuberculosis (M. tuberculosis) in eastern China. METHODS AND RESULTS The mutations of rpoB gene in 56 clinical isolates of M. tuberculosis resisted to one to four first-line drugs (rifampin, isonicotinyl hydrazide, ethambutol and streptomycin) were analysed by polymerase chain reaction single strand conformation polymorphism analysis (PCR-SSCP) and DNA… CONTINUE READING