Characterization of rotavirus replication intermediates: a model for the assembly of single-shelled particles.

@article{Gallegos1989CharacterizationOR,
  title={Characterization of rotavirus replication intermediates: a model for the assembly of single-shelled particles.},
  author={C O Gallegos and John T Patton},
  journal={Virology},
  year={1989},
  volume={172 2},
  pages={616-27}
}
The segmented double-stranded (ds)RNA genome of the rotaviruses is replicated asymmetrically with viral mRNA serving as the template for minus-strand RNA synthesis. To identify intermediate structures in rotavirus replication, subviral particles (SVPs) purified from the cytoplasm of simian rotavirus SA11-infected cells were assayed for RNA polymerase activity in a cell-free system that supports viral RNA replication. Intact SVPs containing newly made RNA were resolved by electrophoresis under… CONTINUE READING

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The segmented double - stranded ( ds)RNA genome of the rotaviruses is replicated asymmetrically with viral mRNA serving as the template for minus - strand RNA synthesis .
The segmented double - stranded ( ds)RNA genome of the rotaviruses is replicated asymmetrically with viral mRNA serving as the template for minus - strand RNA synthesis .
The segmented double - stranded ( ds)RNA genome of the rotaviruses is replicated asymmetrically with viral mRNA serving as the template for minus - strand RNA synthesis .
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