Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model.

@article{Ehrich1999CharacterizationOR,
  title={Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model.},
  author={Elliot W. Ehrich and Aimee L Dallob and Inge de Lepeleire and Anne van Hecken and Diane Riendeau and Wenli Yuan and Ana I Porras and Joseph Anthony Wittreich and James R. Seibold and Paul De Schepper and Donald R. Mehlisch and Barry J. Gertz},
  journal={Clinical pharmacology and therapeutics},
  year={1999},
  volume={65 3},
  pages={
          336-47
        }
}
BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and indomethacin (INN, indometacin) inhibit both the constitutive (COX-1) and inducible (COX-2) isoforms of cyclooxygenase. The induction of COX-2 after inflammatory stimuli has led to the hypothesis that COX-2 inhibition primarily accounts for the therapeutic properties of NSAIDs. METHODS Chinese hamster ovary (CHO) cell lines that express each COX isoform were used to characterize the in vitro selectivity… CONTINUE READING
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