Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect.

@article{Hariharan1995CharacterizationOR,
  title={Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect.},
  author={Iswar K Hariharan and Kang Quan Hu and H Asha and Adrian Quintanilla and Robert M. Ezzell and Jeffrey Settleman},
  journal={The EMBO journal},
  year={1995},
  volume={14 2},
  pages={292-302}
}
The rho family of GTPases has been implicated in regulating changes in cell morphology in response to extracellular signals. We have cloned three widely expressed members of this family from Drosophila melanogaster; a rho homologue (Rho1) and two rac homologues (Rac1 and Rac2). Flies harbouring a Rho1 transgene that is specifically expressed in the eye exhibit a dramatic dose dependent disruption of normal eye development. Flies bearing at least two copies of the transgene display a severe… CONTINUE READING

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