Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro.

@article{Migliaccio2003CharacterizationOR,
  title={Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro.},
  author={Giovanni Migliaccio and Joanne E. Tomassini and Steven S. Carroll and Licia Tomei and Sergio Altamura and B. Shyamasundara Bhat and Linda Bartholomew and Michele R Bosserman and Alessandra Ceccacci and Lawrence F Colwell and Riccardo Cortese and Raffaele De Francesco and Anne B Eldrup and Krista L Getty and Xiaoli Shirley Hou and Robert L Lafemina and Steven W. Ludmerer and Malcolm Maccoss and Daniel R. McMasters and Mark W Stahlhut and David B. Olsen and Daria Hazuda and Osvaldo A. Flores},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 49},
  pages={49164-70}
}
The urgent need for efficacious drugs to treat chronic hepatitis C virus (HCV) infection requires a concerted effort to develop inhibitors specific for virally encoded enzymes. We demonstrate that 2'-C-methyl ribonucleosides are efficient chain-terminating inhibitors of HCV genome replication. Characterization of drug-resistant HCV replicons defined a single S282T mutation within the active site of the viral polymerase that conferred loss of sensitivity to structurally related compounds in both… CONTINUE READING
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