Characterization of renal papillary antigen 1 (RPA-1), a biomarker of renal papillary necrosis.

@article{Price2010CharacterizationOR,
  title={Characterization of renal papillary antigen 1 (RPA-1), a biomarker of renal papillary necrosis.},
  author={Sally Amanda Price and Dai Davies and Rachel A. Rowlinson and Clive G Copley and Andrew Roche and Frank W. Falkenberg and Daniela Riccardi and Graham R. Betton},
  journal={Toxicologic pathology},
  year={2010},
  volume={38 3},
  pages={346-58}
}
Renal papillary necrosis (RPN) is a relatively common toxicity observed in preclinical drug safety testing. It is also observed in a variety of human diseases. RPN is difficult to diagnose without expensive scanning methods or histopathology. A noninvasive biomarker that could be detected at early stages of kidney damage would be of great value both to preclinical drug safety testing and in the clinic. An antibody raised to an unknown epitope of an antigen in rat kidney papilla was found to be… CONTINUE READING

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