Characterization of recombinantly expressed rat and monkey intestinal alkaline phosphatases: in vitro studies and in vivo correlations.

@article{Subramanian2013CharacterizationOR,
  title={Characterization of recombinantly expressed rat and monkey intestinal alkaline phosphatases: in vitro studies and in vivo correlations.},
  author={Murali Subramanian and Sundeep Paruchury and Shashyendra Singh Gautam and Sheelendra Pratap Singh and Rambabu Arla and Sonia Pahwa and Snehasis Jana and Prasannakumar Katnapally and Vadari Yoganand and Basanth Lakshmaiah and Debarati Mazumder Tagore and Kaushik Ghosh and Punit H. Marathe and Sandhya Mandlekar},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2013},
  volume={41 7},
  pages={1425-32}
}
Intestinal alkaline phosphatases (IALPs) are widely expressed in the brush border of epithelial cells of the intestinal mucosa. Although their physiologic role is unclear, they are very significant when it comes to the release of bioactive parent from orally dosed phosphate prodrugs. Such prodrugs can be resistant to cleavage by IALP, or alternatively undergo rapid cleavage leading to the release and precipitation of the less soluble parent. Because purified IALPs from preclinical species are… CONTINUE READING