Characterization of recombinant REGalpha, REGbeta, and REGgamma proteasome activators.

  title={Characterization of recombinant REGalpha, REGbeta, and REGgamma proteasome activators.},
  author={Claudio A. Realini and Christopher C. Jensen and Zhiguo Zhang and Steven C. Johnston and J. Randolph Knowlton and Christopher P Hill and Martin Rechsteiner},
  journal={The Journal of biological chemistry},
  volume={272 41},
Full-length cDNAs for three human proteasome activator subunits, called REGalpha, REGbeta, and REGgamma, have been expressed in Escherichia coli, and the purified recombinant proteins have been characterized. Recombinant alpha or gamma subunits form heptameric species; recombinant beta subunits are found largely as monomers or small multimers. Each recombinant REG stimulates cleavage of fluorogenic peptides by human red cell proteasomes. The pattern of activated peptide hydrolysis is virtually… CONTINUE READING
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