Characterization of receptors mediating vascular responses to endothelin-1 in the conscious rat.

@article{Filep1994CharacterizationOR,
  title={Characterization of receptors mediating vascular responses to endothelin-1 in the conscious rat.},
  author={J{\'a}nos G. Filep and Martine Clozel and Alain Fournier and E F{\"o}ldes-Filep},
  journal={British journal of pharmacology},
  year={1994},
  volume={113 3},
  pages={845-52}
}
1. The present study has determined the receptors mediating the vascular responses (pressor and depressor actions and vascular permeability effect) to endothelin-1 (ET-1) in the conscious rat by using the novel non-peptide ETA/ETB receptor antagonist, bosentan (Ro 47-0203, 4-tert-butyl-N-[6-(2 hydroxyethoxy)-5-(2-methoxy-phenoxy)-2,2'-bipyrimidine- 4-yl]benzene-sulphonamide), the ETA receptor-selective antagonist, FR 139317 and the ETB receptor-selective peptide agonist, IRL 1620. 2. Bolus… CONTINUE READING
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