Characterization of rat intestinal angiotensin II receptors.

  title={Characterization of rat intestinal angiotensin II receptors.},
  author={Marte Schinke and Henri N. Doods and Detlev Ganten and Wolfgang Wienen and Michael Entzeroth},
  journal={European journal of pharmacology},
  volume={204 2},
In rat ileum and duodenum 125I-sarcosine1,isoleucine8-angiotensin II labels a single population of binding sites with comparable receptor densities of 98 and 94 fmol/mg protein, respectively. Radioligand binding was dose dependently antagonized by angiotensin II (AII) and related peptides. DuP 753, a selective antagonist for the angiotensin AT1 receptor subtype, potently inhibited radioligand binding in both tissues (Ki: 12.7 and 11.8 nM), while AT2-selective ligands like PD 123.177 or p-amino… CONTINUE READING
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