Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases.

@article{Bnard1999CharacterizationOR,
  title={Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases.},
  author={Val{\'e}rie B{\'e}nard and Benjamin Bohl and Gary M. Bokoch},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 19},
  pages={13198-204}
}
A major function of Rac2 in neutrophils is the regulation of oxidant production important in bacterial killing. Rac and the related GTPase Cdc42 also regulate the dynamics of the actin cytoskeleton, necessary for leukocyte chemotaxis and phagocytosis of microorganisms. Although these GTPases appear to be critical downstream components of chemoattractant… CONTINUE READING