Characterization of putative glycoinositol phospholipid anchor precursors in mammalian cells. Localization of phosphoethanolamine.

@article{Hirose1992CharacterizationOP,
  title={Characterization of putative glycoinositol phospholipid anchor precursors in mammalian cells. Localization of phosphoethanolamine.},
  author={Shigehisa Hirose and Greg Prince and Daniel Sevlever and Lakshmeswari Ravi and Terrone L. Rosenberry and Eiichi Ueda and M. Edward Medof},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 24},
  pages={16968-74}
}
A number of mammalian cell surface proteins are anchored by glycoinositol phospholipid (GPI) structures that are preassembled and transferred to them in the endoplasmic reticulum. The GPIs in these proteins contain linear ethanolamine (EthN)-phosphate (P)-6ManManManGlcN core glycan sequences bearing an additional EthN-P attached to the Man residue (Man 1) proximal to GlcN. The biochemical precursors of mammalian GPI anchor structures are incompletely characterized. In this study, putative [3H… CONTINUE READING

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