Characterization of protein transacetylase from human placenta as a signaling molecule calreticulin using polyphenolic peracetates as the acetyl group donors

@article{Seema2007CharacterizationOP,
  title={Characterization of protein transacetylase from human placenta as a signaling molecule calreticulin using polyphenolic peracetates as the acetyl group donors},
  author={Seema and R. Sarala Kumari and Garima Gupta and Daman Saluja and Ajit Kumar and Sanjay Goel and Yogesh Kumar Tyagi and Ruchika Gulati and Anjali Vinocha and Kambadoor Muralidhar and Bilikere S. Dwarakanth and Ramesh Chandra Rastogi and Virinder Singh Parmar and Shamkant Anant Patkar and Hanumantharao Guru Raj},
  journal={Cell Biochemistry and Biophysics},
  year={2007},
  volume={47},
  pages={53-64}
}
We have earlier shown that a unique membrane-bound enzyme mediates the transfer of acetyl group(s) from polyphenolic peracetates (PA) to functional proteins, which was termed acetoxy drug: protein transacetylase (TAase) because it acted upon several classes of PA. Here, we report the purification of TAase from human placentral microsomes to homogeneity with molecular mass of 60 kDa, exhibiting varying degrees of specificity to several classes of PA confirming the structure-activity relationship… CONTINUE READING
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Acetoxy drug: protein transacetylase: A novel enzyme-mediating protein acetylation by polyphenolic peracetates

  • H. G. Raj, B. K. Singh, E Kohli
  • Pure Appl. Chem
  • 2005

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