Characterization of protective immune responses promoted by human antigen targets in a urogenital Chlamydia trachomatis mouse model.

@article{Olsen2014CharacterizationOP,
  title={Characterization of protective immune responses promoted by human antigen targets in a urogenital Chlamydia trachomatis mouse model.},
  author={Anja Weinreich Olsen and Peter Andersen and Frank Follmann},
  journal={Vaccine},
  year={2014},
  volume={32 6},
  pages={
          685-92
        }
}
A vaccine against genital tract infections caused by Chlamydia trachomatis is urgently needed. We have previously identified a number of immunodominant human T- and/or B-cell antigen targets in patients with a C. trachomatis infection. Herein we use a urogenital C. trachomatis mouse model to investigate the protective efficacy of these antigens. C3H/HeN mice were immunized with recombinant antigens formulated in the adjuvant CAF01. Immunity post vaccination was analyzed and the protective… CONTINUE READING

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