Characterization of progressive metaplasia in the gastric corpus mucosa of Mongolian gerbils infected with Helicobacter pylori.

@article{Shimizu2016CharacterizationOP,
  title={Characterization of progressive metaplasia in the gastric corpus mucosa of Mongolian gerbils infected with Helicobacter pylori.},
  author={Takahiro Shimizu and Eunyoung Choi and Christine P. Petersen and Jennifer M Noto and Judith Romero-Gallo and M Blanca Piazuelo and M. Kay Washington and Richard M Peek and James R Goldenring},
  journal={The Journal of pathology},
  year={2016},
  volume={239 4},
  pages={399-410}
}
Spasmolytic polypeptide-expressing metaplasia (SPEM) and intestinal metaplasia are considered neoplastic precursors of gastric adenocarcinoma in humans. Loss of parietal cells causes the development of SPEM in the gastric corpus and then chronic inflammation drives SPEM toward a more proliferative lineage. Mongolian gerbils infected with Helicobacter pylori… CONTINUE READING