Characterization of profilaggrin endoproteinase 1. A regulated cytoplasmic endoproteinase of epidermis.

@article{Resing1995CharacterizationOP,
  title={Characterization of profilaggrin endoproteinase 1. A regulated cytoplasmic endoproteinase of epidermis.},
  author={Katherin A Resing and C E Thulin and K. W. Whiting and N al-Alawi and Sara B Mostad},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 47},
  pages={28193-8}
}
Profilaggrin, an insoluble precursor of the intermediate filament-associated protein filaggrin, contains multiple internal repeats (PIRs). At terminal differentiation of epidermis, proteolytic processing within a "linker" region of each PIR releases soluble filaggrin in a two-stage process. The first stage endoproteinase (PEP1, profilaggrin endoproteinase 1) cleaves mouse profilaggrin at a subset of the linkers, yielding processing intermediates consisting of several filaggrin repeats. An… CONTINUE READING