Characterization of pro-apoptotic and matrix-degradative gene expression following induction of osteoarthritis in mature and aged rabbits.

@article{Robertson2006CharacterizationOP,
  title={Characterization of pro-apoptotic and matrix-degradative gene expression following induction of osteoarthritis in mature and aged rabbits.},
  author={Catherine M. Robertson and Andrew T. Pennock and Frederick L Harwood and Adam C. Pomerleau and Richard Todd Allen and David Amiel},
  journal={Osteoarthritis and cartilage},
  year={2006},
  volume={14 5},
  pages={471-6}
}
OBJECTIVE The genetic and molecular changes leading to the distinctive alterations of aged cartilage and its propensity for developing osteoarthritis (OA) are unknown. We hypothesized that pro-apoptotic and matrix-degradative gene expression in a rabbit model of induced OA using mature and aged animals might elucidate this relationship. METHODS Groups of… CONTINUE READING