Characterization of prejunctional muscarinic autoreceptors in the guinea-pig trachea.

  title={Characterization of prejunctional muscarinic autoreceptors in the guinea-pig trachea.},
  author={Heinz Kilbinger and Renate Schneider and H Siefken and Doris Wolf and Gianluigi D'Agostino},
  journal={British journal of pharmacology},
  volume={103 3},
1. The effects of ten muscarinic antagonists on electrically evoked [3H]-acetylcholine release and muscle contraction were compared in an epithelium-free preparation of the guinea-pig trachea that had been preincubated with [3H]-choline. 2. The M3-selective antagonists UH-AH 37, 4-diphenyl-acetoxy-N-piperidine methobromide and para-fluorohexahydrosiladiphenidol were more potent in reducing the contractile response than in facilitating the evoked [3H]-acetylcholine release… CONTINUE READING

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