Characterization of postsynaptic alpha1-adrenoceptors in the rabbit iris dilator smooth muscle

@article{Konno2004CharacterizationOP,
  title={Characterization of postsynaptic alpha1-adrenoceptors in the rabbit iris dilator smooth muscle},
  author={Fukio Konno and Issei Takayanagi},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={333},
  pages={271-276}
}
  • F. Konno, I. Takayanagi
  • Published 1 July 1986
  • Biology, Medicine, Chemistry
  • Naunyn-Schmiedeberg's Archives of Pharmacology
SummaryInteractions of several alpha-adrenoceptor agonists and antagonists with their receptors were studied in rabbit and guinea pig iris dilator smooth muscle and rabbit aortic strips using pharmacological procedures.In rabbit iris dilators and aortic strips, noradrenaline acted as a full agonist, while oxymetazoline, clonidine and tizanidine acted as partial agonists. The dissociation constants of full and partial agonists in the dilators, calculated after irreversible blockade of a… 
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Investigation of subtypes of alpha‐1 adrenoceptor in rabbit ocular tissues using reverse transcription‐polymerase chain reaction (RT – PCR), in situ hybridization (ISH) and binding studies showed that hybridization signals were clearly observed in the iris dilator muscle and in the epithelium of the ciliary processes.
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