Characterization of postsynaptic alpha1-adrenoceptors in the rabbit iris dilator smooth muscle

@article{Konno1986CharacterizationOP,
  title={Characterization of postsynaptic alpha1-adrenoceptors in the rabbit iris dilator smooth muscle},
  author={Fumihiro Konno and Issei Takayanagi},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1986},
  volume={333},
  pages={271-276}
}
Interactions of several alpha-adrenoceptor agonists and antagonists with their receptors were studied in rabbit and guinea pig iris dilator smooth muscle and rabbit aortic strips using pharmacological procedures. In rabbit iris dilators and aortic strips, noradrenaline acted as a full agonist, while oxymetazoline, clonidine and tizanidine acted as partial agonists. The dissociation constants of full and partial agonists in the dilators, calculated after irreversible blockade of a proportion of… CONTINUE READING

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Comparison of dissociation constants and of relative efficacies of selective agonists acting on parasympathetic receptors

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