Characterization of porphyrin heme oxygenase inhibitors.

  title={Characterization of porphyrin heme oxygenase inhibitors.},
  author={H. Vreman and D A Cipkala and David K. Stevenson},
  journal={Canadian journal of physiology and pharmacology},
  volume={74 3},
Synthetic metalloporphyrin derivatives of heme have been identified as competitive inhibitors of heme oxygenase, the rate-limiting enzyme in the heme degradation pathway that produces equimolar quantities of carbon monoxide, biliverdin, and bilirubin. Therefore, administration of metalloporphyrin has been proposed as one means to prevent excessive hyperbilirubinemia in human neonates. Tin proto- and meso-porphyrin have been studied for the suppression of neonatal jaundice. However, these… CONTINUE READING