Characterization of porcine NLRP3 inflammasome activation and its upstream mechanism

@article{Kim2014CharacterizationOP,
  title={Characterization of porcine NLRP3 inflammasome activation and its upstream mechanism},
  author={Jeeyoung Kim and Huijeong Ahn and Heung-Myong Woo and Eunsong Lee and Geun-Shik Lee},
  journal={Veterinary Research Communications},
  year={2014},
  volume={38},
  pages={193-200}
}
Inflammasomes, which are intracellular sensors of endogenous or exogenous danger signals, activate caspase-1, resulting in interleukin (IL)-1β maturation. Although most studies on inflammasomes have been performed in human and/or mouse-derived macrophages, porcine inflammasome activation has not been elucidated even though pigs are considered one of the best animal models for translational and preclinical investigations. In this study, we optimized detection of porcine IL-1β secretion, which is… CONTINUE READING
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