Characterization of poly(L-glutamic acid)-grafted hyaluronan as a novel candidate medicine and biomedical device for intra-articular injection.

@article{Muramatsu2017CharacterizationOP,
  title={Characterization of poly(L-glutamic acid)-grafted hyaluronan as a novel candidate medicine and biomedical device for intra-articular injection.},
  author={Kazuaki Muramatsu and Yuya Tajima and Rin Kaneko and Yuta Yanagita and Hiroyuki Hirai and Nana Hiura},
  journal={Journal of biomedical materials research. Part A},
  year={2017},
  volume={105 11},
  pages={
          3006-3016
        }
}
A novel hyaluronan (HA) derivative, poly(L-glutamic acid)-grafted hyaluronan (PGA-g-HA), was synthesized to improve the durability of conventional HA products for intra-articular injection. The purpose of this study was to investigate the characteristics of the novel HA derivative in terms of viscoelasticity, degradation behavior, non-immunogenicity, and bioactivity using preliminary in vitro and in vivo experiments. The storage modulus (G') and loss modulus (G″) of PGA-g-HA were similar to… CONTINUE READING

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