Characterization of platinum anticancer drug protein-binding sites using a top-down mass spectrometric approach.

@article{Hartinger2008CharacterizationOP,
  title={Characterization of platinum anticancer drug protein-binding sites using a top-down mass spectrometric approach.},
  author={Christian G Hartinger and Yury O Tsybin and Jens Fuchser and Paul J Dyson},
  journal={Inorganic chemistry},
  year={2008},
  volume={47 1},
  pages={17-9}
}
A proof-of-principle study on the application of a top-down electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric approach for characterization of the primary binding sites of the platinum anticancer agents cisplatin, transplatin, and oxaliplatin on ubiquitin is presented. Through employment of different fragmentation techniques, the binding sites of cisplatin and oxaliplatin were found at N-terminal methionine-containing ubiquitin fragments, while transplatin was… CONTINUE READING