Characterization of platelet-derived growth factor-C (PDGF-C): expression in normal and tumor cells, biological activity and chromosomal localization.

@article{Dijkmans2002CharacterizationOP,
  title={Characterization of platelet-derived growth factor-C (PDGF-C): expression in normal and tumor cells, biological activity and chromosomal localization.},
  author={Joyce Dijkmans and Jean Xu and Stefan Masure and Sridevi Dhanaraj and Anna Gosiewska and Jeff Geesin and J{\"o}rg Sprengel and Sarah E Harris and Peter Verhasselt and Robert Gordon and Jeff Yon},
  journal={The international journal of biochemistry & cell biology},
  year={2002},
  volume={34 4},
  pages={414-26}
}
The predicted platelet-derived growth factor-C (PDGF-C) polypeptide contains an N-terminal CUB-like domain and a C-terminal domain with homology to members of the PDGF/vascular endothelial growth factor (VEGF) family. PDGF-C mRNA is widely expressed in normal tissues and does not appear to be up-regulated in the tumor cell lines tested. The PDGF-C gene was mapped to human chromosome 4q31-32. PDGF-C protein and the CUB domain of PDGF-C expressed in Escherichia coli, were able to stimulate… CONTINUE READING