Characterization of phospholipase C from Pseudomonas aeruginosa as a potent inflammatory agent.

@article{Meyers1990CharacterizationOP,
  title={Characterization of phospholipase C from Pseudomonas aeruginosa as a potent inflammatory agent.},
  author={D J Meyers and Richard S. Berk},
  journal={Infection and immunity},
  year={1990},
  volume={58 3},
  pages={659-66}
}
Phospholipase C (PLC) from Pseudomonas aeruginosa induced a marked inflammatory response when injected intraperitoneally in C3H/HeJ mice. This inflammation was characterized by the accumulation of inflammatory cells and plasma protein and the release of arachidonic acid metabolites (6-trans-12-epi-leukotriene B4 [LTB4], 6-trans-LTB4, LTB4, 5-HETE (5-hydroxyeicosatetraenoic acid), LTC4, LTD4, LTE4, prostaglandin E2 [PGE2], PGF2-alpha, and thromboxane B2 [TxB2]) in the peritoneal cavity of the… CONTINUE READING

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