Characterization of phosphodiesterase type 5 expression and functional activity in the human male lower urinary tract.

@article{Fibbi2010CharacterizationOP,
  title={Characterization of phosphodiesterase type 5 expression and functional activity in the human male lower urinary tract.},
  author={Benedetta Fibbi and Annamaria Morelli and Linda 4 Vignozzi and Simonetta Filippi and Aravinda Krishnappa Chavalmane and Giulia de Vita and Mirca Marini and Mauro Gacci and Gabriella Barbara Vannelli and Peter Sandner and Mario Maggi},
  journal={The journal of sexual medicine},
  year={2010},
  volume={7 1 Pt 1},
  pages={
          59-69
        }
}
INTRODUCTION Phosphodiesterase type 5 (PDE5) inhibitors ameliorate low urinary tract (LUT) symptoms in men with ED and symptomatic benign prostatic hyperplasia (BPH). PDE5 is highly expressed in rat and human bladder, where it regulates cyclic guanosine monophosphate (cGMP) degradation, muscle tone, and proliferation. AIM To investigate PDE5 tissue distribution and activity in human LUT tissues (urethra, prostate, and bladder). MAIN OUTCOME MEASURES PDE5 expression and activity were… CONTINUE READING
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