Characterization of phenytoin-resistant kindled rats, a new model of drug-resistant partial epilepsy: influence of experimental and environmental factors

@article{Ebert1999CharacterizationOP,
  title={Characterization of phenytoin-resistant kindled rats, a new model of drug-resistant partial epilepsy: influence of experimental and environmental factors},
  author={Ulrich Ebert and Chris Rundfeldt and Holger Lehmann and Wolfgang L{\"o}scher},
  journal={Epilepsy Research},
  year={1999},
  volume={33},
  pages={199-215}
}
It has been recently shown that the variable anticonvulsant effect of phenytoin in the kindling model is not a characteristic of all kindled rats. In a population of amygdala-kindled Wistar rats, subgroups can be selected which consistently respond to phenytoin with an increase in afterdischarge threshold (responders) or which never show such an increase (non-responders). This study examined retrospectively the influence of technical and environmental factors on the results of several… CONTINUE READING
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