Characterization of permeability, stability and anti-HIV-1 activity of decitabine and gemcitabine divalerate prodrugs.

@article{Clouser2014CharacterizationOP,
  title={Characterization of permeability, stability and anti-HIV-1 activity of decitabine and gemcitabine divalerate prodrugs.},
  author={Christine L. Clouser and Laurent Bonnac and Louis M Mansky and Steven E. Patterson},
  journal={Antiviral chemistry & chemotherapy},
  year={2014},
  volume={23 6},
  pages={223-30}
}
BACKGROUND Over 25 drugs have been approved for the treatment of HIV-1 replication. All but one of these drugs is delivered as an oral medication. Previous studies have demonstrated that two drugs, decitabine and gemcitabine, have potent anti-HIV-1 activities and can work together in synergy to reduce HIV-1 infectivity via lethal mutagenesis. For their current indications, decitabine and gemcitabine are delivered intravenously. METHODS As an initial step towards the clinical translation of… CONTINUE READING