Characterization of p87C3G, a novel, truncated C3G isoform that is overexpressed in chronic myeloid leukemia and interacts with Bcr-Abl.

@article{GutirrezBerzal2006CharacterizationOP,
  title={Characterization of p87C3G, a novel, truncated C3G isoform that is overexpressed in chronic myeloid leukemia and interacts with Bcr-Abl.},
  author={Javier Guti{\'e}rrez-Berzal and Esther Castellano and Susana Mart{\'i}n-Encabo and Noelia Guti{\'e}rrez-Cianca and Jes{\'u}s M. Hern{\'a}ndez and Eugenio Santos and Carmen Guerrero},
  journal={Experimental cell research},
  year={2006},
  volume={312 6},
  pages={938-48}
}
A novel C3G isoform, designated p87C3G, lacking the most amino terminal region of the cognate protein has been found to be overexpressed in two CML cell lines, K562 and Boff 210, both expressing Bcr-Abl p210. p87C3G expression is also highly augmented in patients diagnosed with chronic myeloid leukemia (CML) Ph+, in comparison with healthy individuals, and returns to basal levels after treatment with STI571. p87C3G co-immunoprecipitates with both CrkL and Bcr-Abl in CML cell lines and co… CONTINUE READING

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