Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction.

@article{Chen1996CharacterizationOP,
  title={Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction.},
  author={I T Chen and Miki Akamatsu and Martin L. Smith and F D Lung and Diane Duba and Peter P. Roller and Albert J. Fornace and Patrick M. O'Connor},
  journal={Oncogene},
  year={1996},
  volume={12 3},
  pages={595-607}
}
The cyclin-dependent kinase inhibitor p21Cip1/Waf1 is responsible for the p53-dependent growth arrest of cells in G1 phase following DNA damage. In the present study we investigated regions of p21 involved in inhibition of the G1/S phase cyclin-dependent kinase, cyclin E/Cdk2, as well as regions of p21 important for binding to this kinase and recombinant PCNA. To perform these studies we synthesized a series of overlapping peptides spanning the entire p21 sequence and used them in in vitro… CONTINUE READING

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