Characterization of osthenol metabolism in vivo and its pharmacokinetics

@article{Cho2019CharacterizationOO,
  title={Characterization of osthenol metabolism in vivo and its pharmacokinetics},
  author={P. Cho and Su Min Choi and Younah Kim and Doohyun Lee and Y. Noh and Sujeong Kim and Ju Hyun Kim and Taeho Lee and Sangkyu Lee},
  journal={Xenobiotica},
  year={2019},
  volume={50},
  pages={839 - 846}
}
Abstract Osthenol, a prenylated coumarin, is a C8-prenylated derivative of umbelliferone isolated from the root of Angelica koreana and Angelica dahurica, an intermediate and is known as a major metabolite of desmethyl-osthole. The various pharmacological effects of osthenol have been reported. In previous studies, we investigated five hydroxylated metabolites by cytochromes P450 (CYP) and glucuronide conjugates of osthenol by uridine diphosphate-glucuronosyltransferases (UGTs). However… Expand
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