Characterization of nucleic acid higher order structure by gas-phase H/D exchange in a quadrupole-FT-ICR mass spectrometer.

@article{Mo2009CharacterizationON,
  title={Characterization of nucleic acid higher order structure by gas-phase H/D exchange in a quadrupole-FT-ICR mass spectrometer.},
  author={Jingjie Mo and Gabrielle C. Todd and Kristina H{\aa}kansson},
  journal={Biopolymers},
  year={2009},
  volume={91 4},
  pages={256-64}
}
Nucleic acid higher order structure is of intense interest in antisense and antigene strategies toward novel chemotherapeutic agents. Understanding how structural characteristics affect solution-phase properties is essential for a rational approach to nucleic acid-targeted drug design. The most dominant nucleic acid secondary structure is the hairpin… CONTINUE READING