Characterization of nuclear localization signals and cytoplasmic retention region in the nuclear receptor CAR.

@article{Kanno2005CharacterizationON,
  title={Characterization of nuclear localization signals and cytoplasmic retention region in the nuclear receptor CAR.},
  author={Yuichiro Kanno and Motoyoshi Suzuki and Takayuki Nakahama and Yoshio Inouye},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1745 2},
  pages={215-22}
}
The constitutive androstane receptor (CAR) is a ligand/activator-dependent transactivation factor that resides in the cytoplasm and forms part of an as yet unidentified protein complex. Upon stimulation, CAR translocates into the nucleus where it modulates the transactivation of target genes. However, CAR exogenously expressed in rat liver RL-34 cells is located in the nucleus even in the absence of activators. By transiently transfecting RL-34 cells with various mutated rat CAR segments, we… CONTINUE READING

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