Characterization of novel phosphodiesterases in the bovine ovarian follicle.

@article{Sasseville2009CharacterizationON,
  title={Characterization of novel phosphodiesterases in the bovine ovarian follicle.},
  author={Maxime Sasseville and Firas K. Albuz and Nancy C{\^o}t{\'e} and Christine Guillemette and Robert Bruce Gilchrist and François J. Richard},
  journal={Biology of reproduction},
  year={2009},
  volume={81 2},
  pages={
          415-25
        }
}
The phosphodiesterase (PDE) family is a group of enzymes that catalyzes the transformation of cyclic nucleotides into 5' nucleotides. Based on rodents, the current mammalian model of PDE distribution in the ovarian follicle predicts Pde3a in the oocyte and Pde4d in the somatic cells. Using bovine as an experimental model, the present results showed that PDE3 was the predominant PDE activity in oocytes. However, cumulus cell cAMP-PDE activity was predominantly resistant to inhibition by 3… CONTINUE READING

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