Characterization of nociceptin/orphanin FQ-induced pain responses in conscious mice: neonatal capsaicin treatment and N-methyl-D-aspartate receptor GluRepsilon subunit knockout mice.

@article{Minami2000CharacterizationON,
  title={Characterization of nociceptin/orphanin FQ-induced pain responses in conscious mice: neonatal capsaicin treatment and N-methyl-D-aspartate receptor GluRepsilon subunit knockout mice.},
  author={Toshiaki Minami and Emiko Okuda-Ashitaka and Hidemaro Mori and Kenji Sakimura and Masahiko Watanabe and Masayoshi Mishina and Seiji Ito},
  journal={Neuroscience},
  year={2000},
  volume={97 1},
  pages={133-42}
}
Activation of primary afferent C fibers gives rise to spinal release of substance P and glutamate, and these mediators facilitate the cascade of nociceptive processing. We recently showed that intrathecal administration of nociceptin or orphanin FQ (hereafter called nociceptin) induced hyperalgesia to noxious thermal stimuli and allodynia to innocuous tactile stimuli applied to conscious mice. In the present study, we designed experiments to elucidate the pathways and mediators of nociceptin… CONTINUE READING