Characterization of nicotinamide methyltransferase in livers of mice bearing Ehrlich ascites tumors: preferential increase of activity.

  title={Characterization of nicotinamide methyltransferase in livers of mice bearing Ehrlich ascites tumors: preferential increase of activity.},
  author={Y Hanazawa and Kunie Sato and Namiko Kuroiwa and M Ogawa and Akira Kuriyama and Mineko Asanagi and N. Kato and Y Moriyama and Keisuke Horitsu and Shinji Fujimura},
  journal={Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine},
  volume={15 1},
  • Y. Hanazawa, K. Sato, +7 authors S. Fujimura
  • Published 1994
  • Biology, Medicine
  • Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
There was a 2- to 7-fold increase in nicotinamide methyltransferase activity in the livers of mice and rats bearing seven different kinds of tumors compared with the respective control normal livers, while activity in the tumors themselves was hardly detectable. The activity in the liver started to increase markedly 3-7 days after i.p. transplantation of Ehrlich ascites tumors into the mice, maintaining a plateau up to death. Metabolic conversion of 14C-nicotinamide to 14C-N1-methylnicotinamide… Expand
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Histone Deacetylase Inhibitor Depsipeptide Represses Nicotinamide N-Methyltransferase and Hepatocyte Nuclear Factor-1β Gene Expression in Human Papillary Thyroid Cancer Cells
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