Characterization of new polymorphisms in the 5′UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level

@article{Bergholdt2000CharacterizationON,
  title={Characterization of new polymorphisms in the 5′UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level},
  author={Regine Bergholdt and Z. M. Larsen and N E Andersen and Jesper Johannesen and O P Kristiansen and Thomas Mandrup-Poulsen and J\orn Nerup and Flemming Pociot},
  journal={Genes and Immunity},
  year={2000},
  volume={1},
  pages={495-500}
}
The human interleukin-1 type I receptor (IL-1RI) is the signal transducing receptor for IL-1, a principal proinflammatory cytokine, which is cytotoxic to pancreatic islet beta cells. The IL-1RI gene, IL1R1, maps to chromosome 2q12. We have previously examined part of the IL1R1 promoter region and in the present study we further characterized the promoter region demarcating exon 1B and 1C by sequencing and mutation scanning. New sequence was obtained 1762 bp upstream and 1609 bp downstream the… CONTINUE READING

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