Characterization of new mutations in pyrazinamide-resistant strains of Mycobacterium tuberculosis and identification of conserved regions important for the catalytic activity of the pyrazinamidase PncA.

@article{Lematre1999CharacterizationON,
  title={Characterization of new mutations in pyrazinamide-resistant strains of Mycobacterium tuberculosis and identification of conserved regions important for the catalytic activity of the pyrazinamidase PncA.},
  author={Nadine Lema{\^i}tre and Wladimir Sougakoff and Chantal Truffot-Pernot and Vincent Jarlier},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 7},
  pages={
          1761-3
        }
}
A new set of mutations, including transposition of the insertion sequence IS6110, was identified in the pncA gene from 19 pyrazinamide-resistant Mycobacterium tuberculosis strains. Alignment of the PncA protein from M. tuberculosis with homologous proteins from different bacterial species revealed three highly conserved regions in PncA which may play an important role in the processing of pyrazinamide. 
Highly Cited
This paper has 97 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

Mycobacterium tuberculosis isolates from Rio de Janeiro reveal unusually low correlation between pyrazinamide resistance and mutations in the pncA gene.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases • 2013
View 4 Excerpts
Highly Influenced

Characteristics of pncA mutations in multidrug-resistant tuberculosis in Taiwan

BMC infectious diseases • 2011
View 10 Excerpts
Highly Influenced

97 Citations

051015'00'04'09'14'19
Citations per Year
Semantic Scholar estimates that this publication has 97 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 11 references

Differences in the prevalence of IS6110 insertion sites in Mycobacterium tuberculosis strains: low and high copy number of IS6110

N. Fomukong, M. Beggs, +3 authors M. D. Cave
Tuber. Lung Dis • 1998

Genotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from Peru

Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease • 1998
View 2 Excerpts

Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update.

Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease • 1998
View 1 Excerpt

Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis.

Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease • 1997
View 3 Excerpts