Characterization of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genome

@inproceedings{Driessche2016CharacterizationON,
  title={Characterization of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genome},
  author={Beno{\^i}t Van Driessche and Anthony Rodari and Nad{\'e}ge Delacourt and Sylvain Fauquenoy and Caroline Vanhulle and Ars{\`e}ne Burny and Olivier Rohr and Carine van Lint},
  booktitle={Scientific reports},
  year={2016}
}
Bovine leukemia virus latency is a viral strategy used to escape from the host immune system and contribute to tumor development. However, a highly expressed BLV micro-RNA cluster has been reported, suggesting that the BLV silencing is not complete. Here, we demonstrate the in vivo recruitment of RNA polymerase III to the BLV miRNA cluster both in BLV-latently infected cell lines and in ovine BLV-infected primary cells, through a canonical type 2 RNAPIII promoter. Moreover, by RPC6-knockdown… CONTINUE READING
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